Research

Brain Response Test Reveals Hearing Clarity

Babies are too young to do hearing tests until 8 to 10 months of age, and at such young ages, tracking brain waves to sounds is the only reliable way to assess hearing. 

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Effects of Cochlear Implantation and Steroids on the Aging Guinea Pig Cochlea

The causes behind residual hearing loss following cochlear implantation are complex and varied. Studies such as this one provide clues as to what to focus on in order to improve the acoustic experience of cochlear implant recipients. 

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Meeting Patients Inspires Approach to Treating Ménière’s Disease

I currently work with a mouse model with hearing fluctuation and have a clinical protocol that is performing deep phenotyping of patients with hearing instability, including patients with Ménière’s disease.

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Putting the Brakes on Hyperactivity in the Brain

The road to more effective, less invasive, and faster developing treatments for tinnitus and loudness hyperacusis lies in focusing on the brain and not the ear.

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Regrowing Hair Cells and Nerve Connections to Restore Hearing in Birds

This suggests that birds maintain a precise program for hair cell regeneration that preserves frequency-specific nerve connections, which is an important aspect of proper functional recovery.

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Understanding Pain Signals Triggered by Damage to the Inner Ear

Of relevance to hyperacusis, prior noise-induced hearing loss leads to the generation of prolonged and repetitive activity in type II neurons and surrounding tissues. This aberrant signaling may be the basis for the sensitivity to everyday sounds seen in hyperacusis.

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Surprising Role of Auditory Neurons in Learning Revealed by Study in Mice

These findings suggest that the auditory cortex may transmit significant non-auditory signals relevant for learning-related plasticity.

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How the Brain Filters Out Tinnitus Signals in Mild Cases

As a result, increased prefrontal activity may be helpful in improving gating function (automatic filtering), a topic for future research.

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Gene Therapy for Hearing Loss: Interpreting Preliminary Clinical Trial Results

Our independent analysis of the clinical trials’ published data yields the following insights on gene therapy for hearing loss from otoferlin variants. The clinical trials provide the first validation of pharmacological treatments for hearing loss.

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Cochlear Organoids Reveal How Supporting Cells Differentiate Into Hair Cells 

These details gleaned from this regenerative process in the mouse organoid provides insights into how mammalian supporting cells could be reprogrammed into hair cells.

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